Penultimate version, prior to translation into Italian for publication as Chapter 27 in Daniel Garber, ed., L’Età della Rivoluzione Scientifica (Vol 5. of Storia della Scienza Istituto della Enciclopedia Italiana, 2002) pp. 337-357. Intended title in English was, ‘The Organisation of Knowledge: The Grand Programs of Natural Philosophy and the Rise of Disciplinary Differentiation by the End of the Seventeenth Century’ The Italian version contains some changes and additions and should be consulted.